Basic/Translational Research

Joao Luis Carvalho de Souza, DVM , PhD

Ion channels biophysics

• Mechanisms of voltage sensing in ion channels
• Non-canonical mechanisms of voltage-gating in ion channels
• Study of natural variants of ion channels related to human neurological disorders such as epilepsy and ataxia

Retinas rehabilitation using gold-nanoparticles

• Development of a non-genetic, non-implantation technique to re-enable photosensitivity in retinas

Andreia Z. Chignalia, PharmD, PhD

Heart Failure

• Cardiac Remodeling during Chronic Heart Failure: focus on cardiomyocyte proliferation and differentiation
• Pulmonary vascular dysfunction during acute heart failure

Hypertension

• Adrenergic signaling and vascular dysfunction in essential hypertension
• Heparan sulfate proteoglycans in hypertensive disease

Oxidative stress

• Reactive oxygen species and cell fate
• Reactive oxygen species and cardiovascular remodeling
• Oxidative signaling in the regulation of lung permeability